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Synonym: N-phenylacetyl-Lprolylglycine ethyl ester.
CAS Number: 157115-85-0
Formula: C17H22N2O4
Molar mass : 318.4 g/mol
Purity : ≥99.3%
Noopept is a synthetic nootropic compound that is often used to enhance cognitive function, particularly memory, focus, and learning capacity. It is sometimes considered part of the racetam family of nootropics due to its structural and functional similarities, though it is technically not a racetam. Noopept is widely known for its neuroprotective and cognitive-enhancing effects and is believed to work by modulating certain neurotransmitters and improving brain health.
Key Features of Noopept:
Chemical Structure:
- Structural Similarity to Piracetam: Noopept is structurally related to piracetam, one of the first nootropics developed. However, Noopept is much more potent, with effects reported to be 1,000 times stronger than piracetam on a per milligram basis.
- N-Phenylacetyl-L-prolylglycine Ethyl Ester: Chemically, Noopept is a peptide-like compound that is thought to work by influencing various neurotransmitter systems and by exerting neuroprotective actions.
Mechanism of Action:
The exact mechanisms by which Noopept works are not fully understood, but several pathways have been proposed:
- Increased Acetylcholine Activity: Noopept may increase the availability of acetylcholine, a neurotransmitter involved in memory, learning, and cognitive processes.
- Glutamate Modulation: Noopept is believed to affect glutamate receptors, particularly AMPA and NMDA receptors. These receptors are crucial for synaptic plasticity, which is the brain’s ability to reorganize itself by forming new neural connections, and are vital for learning and memory.
- BDNF and NGF Upregulation: Noopept has been shown to increase levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). These proteins are important for neuron growth, repair, and synaptic plasticity, thus promoting overall brain health and function.
- Antioxidant and Neuroprotective Effects: Noopept may act as an antioxidant, helping to reduce oxidative stress and inflammation in the brain. This is thought to contribute to its neuroprotective properties, which may help prevent cognitive decline and support long-term brain health.
Effects:
Noopept is primarily known for its effects on cognition, though it may also have mood-related benefits:
- Enhanced Memory and Learning: Noopept is often used to improve short-term memory, recall, and learning speed. Users report better retention of information and the ability to process complex information more efficiently.
- Improved Focus and Concentration: Some users report an increase in mental clarity, focus, and the ability to concentrate for extended periods. This makes Noopept popular among students and professionals seeking cognitive enhancement.
- Anxiolytic Effects: In some cases, Noopept may reduce anxiety and stress levels, leading to improved mood and emotional stability. This could be related to its effects on neurotransmitter balance and brain health.
- Neuroprotection: Noopept is used not just for its short-term cognitive benefits but also for its potential neuroprotective effects, which may help prevent cognitive decline or age-related brain disorders.
Onset and Duration:
- Onset: Noopept’s effects are typically felt within 15 to 30 minutes of ingestion.
- Duration: The cognitive-enhancing effects last for about 3 to 5 hours.
Dosage:
Noopept is potent, so relatively small doses are needed compared to other nootropics:
- Typical Dosage: The standard dosage is between 10 mg to 30 mg per day, divided into two or three doses. It is often recommended to start with lower doses and increase gradually based on individual response.
- Cycling: Because of its potency, many users recommend cycling Noopept (e.g., taking it for several weeks, followed by a break) to avoid building tolerance.
Potential Side Effects:
Although Noopept is generally well-tolerated, some users may experience side effects, particularly if taken in high doses:
- Headaches: One of the most common side effects, possibly due to increased demand for acetylcholine. Taking a choline source (like Alpha-GPC or Citicoline) may help mitigate this.
- Irritability or Restlessness: Some users report feeling irritable, agitated, or overstimulated after taking Noopept.
- Insomnia: If taken too late in the day, Noopept may cause insomnia or difficulty sleeping due to its stimulatory effects.
- Nausea or Digestive Issues: Occasionally, gastrointestinal discomfort such as nausea or stomach upset may occur.
Comparisons to Other Nootropics:
- Versus Piracetam: Noopept is significantly more potent than piracetam, meaning lower doses are needed to achieve similar or greater cognitive effects. Noopept is also believed to have stronger neuroprotective properties.
- Versus Aniracetam: While both Noopept and aniracetam enhance memory and learning, Noopept is considered more potent and tends to have a more stimulating effect, while aniracetam is often more anxiolytic.
- Versus Modafinil: Noopept is often compared to modafinil for cognitive enhancement, but the two work differently. Modafinil is primarily a wakefulness-promoting agent, while Noopept has more direct effects on memory and learning.
Legal Status:
- United States: In the U.S., Noopept is sold as a dietary supplement or research chemical. It is not approved by the FDA for any medical use but can be purchased online.
- European Union: Noopept is unregulated in many European countries, though it may require a prescription in some regions, such as Russia, where it was originally developed for medical purposes.
- Russia: Noopept is a prescription drug in Russia and is used to treat cognitive impairments and neurodegenerative diseases.
Research and Medical Uses:
- Cognitive Disorders: Noopept was originally developed in Russia as a treatment for cognitive disorders like Alzheimer’s disease, dementia, and age-related cognitive decline.
- Neuroprotection: Animal studies suggest that Noopept may offer neuroprotective benefits, protecting the brain from oxidative damage, inflammation, and excitotoxicity (damage caused by overactive glutamate receptors).
Summary:
Noopept is a powerful nootropic known for its ability to enhance memory, learning, and cognitive function. It works through multiple mechanisms, including increasing acetylcholine activity, modulating glutamate receptors, and promoting the production of BDNF and NGF, which are crucial for brain health. It also exhibits neuroprotective properties, making it popular for both short-term cognitive enhancement and long-term brain health. Although generally safe, side effects like headaches and insomnia can occur, especially with higher doses.
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