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1V LSD (1-valeryl-LSD) is a synthetic lysergamide and a prodrug of LSD (Lysergic acid diethylamide). It is part of a class of psychedelics that closely resemble LSD but feature slight chemical modifications. These changes are designed to alter legal classification or offer a slightly different pharmacological profile. 1V-LSD is chemically similar to other LSD analogs like 1P-LSD and 1cP-LSD.

Key Features of 1V LSD:

Chemical Structure:

• Valeryl Group: The primary chemical distinction of 1V-LSD is the presence of a valeryl group attached to the nitrogen molecule at the indole ring of the LSD backbone. This structural modification makes 1V-LSD a prodrug, meaning it is inactive until metabolized by the body, where it is believed to convert into LSD.
• Lysergamide: Like LSD and its analogs, 1V-LSD is part of the lysergamide family, known for inducing powerful psychedelic experiences, characterized by hallucinations, altered consciousness, and changes in perception.

Mechanism of Action:

1V-LSD works similarly to LSD and other analogs by acting as an agonist at serotonin 5-HT2A receptors in the brain:

• Prodrug to LSD: Once ingested, 1V-LSD is likely metabolized into LSD, which then binds to serotonin receptors. This interaction is responsible for its psychoactive and hallucinogenic effects.
• Serotonin Agonist: By activating serotonin receptors, particularly 5-HT2A, 1V-LSD induces changes in thought patterns, mood, sensory perception, and consciousness. This serotoninergic action is central to the psychedelic effects common to LSD-like substances. 1V LSD

Effects:

The effects of 1V-LSD are reported to be similar to those of traditional LSD:

• Visual Hallucinations: Users typically experience enhanced colors, geometric patterns, and visual distortions, especially with eyes closed. Synesthesia, or mixing of senses (like seeing sounds), may also occur.
• Euphoria and Mood Enhancement: Like LSD, 1V-LSD can produce intense euphoria, emotional openness, and a heightened sense of well-being.
• Altered Perception of Time and Space: Time may feel slowed or distorted, and the sense of space may seem fluid or expansive.
• Introspection and Mystical Experiences: Many users report deep introspection and feelings of spiritual insight or connection to the universe, similar to other psychedelics.
• Cognitive Changes: 1V-LSD can cause thought loops, heightened creativity, and changes in how one processes thoughts and external stimuli. 1V LSD

Onset and Duration:

• Onset: The effects of 1V LSD typically begin within 30 to 90 minutes after ingestion.
• Peak: The peak effects are usually experienced around 2 to 4 hours after onset.
• Duration: The overall duration of effects lasts approximately 8 to 12 hours, similar to traditional LSD, depending on the dose.

Dosage:

1V-LSD is typically taken in micrograms (µg), similar to LSD:

• Threshold Dose: ~25-50 µg
• Common Dose: ~100-150 µg for a full psychedelic experience.
• Higher Doses: ~200 µg or more may produce more intense and long-lasting effects but also increase the risk of overstimulation or challenging trips.

Legal Status:

• European Union: 1V-LSD was developed as a research chemical and designer drug, often used as a legal alternative to LSD in places where LSD is prohibited. However, some countries may have regulated or banned it under analog laws.
• United States: In the U.S., 1V-LSD might be considered illegal under the Federal Analogue Act, which regulates substances that are chemically similar to controlled substances like LSD.
• Germany: In Germany, 1V-LSD was marketed as a legal alternative but was banned as of mid-2022 under the German New Psychoactive Substances Act (NpSG). 1V LSD

Risks and Side Effects:

Like other psychedelics, 1V-LSD carries certain risks:

• Psychological Effects: Some users may experience anxiety, paranoia, or psychological distress during or after the trip, especially at higher doses. Bad trips can be intense and difficult to manage.
• Overstimulation: 1V-LSD can cause insomnia, increased heart rate, and restlessness.
• Flashbacks: Some users may experience flashbacks (spontaneous recurrences of the trip experience) after the drug’s effects have worn off. 1V LSD

Comparisons to Other LSD Analogs:

• Versus LSD: The effects of 1V-LSD are thought to be almost identical to LSD since it metabolizes into LSD. However, users may find subtle differences in the onset and intensity of effects.
• Versus 1P-LSD and 1cP-LSD: 1V-LSD shares similar prodrug properties with 1P-LSD and 1cP-LSD. All three are believed to convert into LSD once ingested, though 1V LSD may have slightly different pharmacokinetics due to the valeryl group.
• Versus AL-LAD or ETH-LAD: These are other lysergamide derivatives, but they tend to have shorter durations and milder visual effects compared to 1V LSD or LSD.

Summary:

1V LSD is a prodrug of LSD designed as a research chemical or designer psychedelic. It shares almost identical effects with LSD, including visual hallucinations, euphoria, and altered perception, but with subtle chemical modifications. Its legal status varies, with some countries banning it under analog laws. Like other psychedelics, 1V-LSD carries risks of bad trips, anxiety, and psychological distress, especially at higher doses. Despite these risks, it remains popular among those seeking experiences similar to LSD but in areas where LSD itself is prohibited.